As OEA can’t undergo any operation without satiate. There are lots of factors are working on it. But the components like PPAR-Alpha, GPR119, and Transient Receptor Potential Vanilloid 1 or TRPV1 are specifically working on it. Moreover, there are other factors like fatty acids, and CD36 also influence the process. Let us see how the three main components contribute to the satiation of OEA.
C-DNA is available is our liver and that is the place where appears produces its clones. From the clones, three types of PPAR produces. Those are alpha, beta-delta, and gamma. Three of them have different functions to play. PPAR-alpha is located at the organs where fatty acid catabolism occurs. This undergoes beta-oxidation in mitochondria, peroxisome, and helps in fatty acid transport.
PPAR-ALPHA helps to bind the UCP2 and FABP with the OEA during the lipid metabolism. It helps in the process of transcription. It also helps to repel the SEA, AEA, and myristolethanolamide from the Oleoylethanolamide to bind during the process. Though there are several fatty acids are acting on PPAR-ALPHA but among them, only oleic acid is effective on it. During hepatocytes, PPAR-ALPHA’s expression is changed by OA, and then it is ready to help OEA.
GPR119 and TRPV1 :
GPR119 is another helping hand of OEA. This protein is located in the gastrointestinal tract and pancreas. This directly acts on insulin and helps to increase the glucose intake. L cell which is responsible for releasing this protein helps to maintain the bodyweight along with food intake. The protein GPR119 helps to stimulate the expression within the genes of OEA and as a result, maintains the food intake. Thus experiment was done on KO Mice to check whether it is also applicable for human beings or not. Moreover, GPR119 protein doesn’t cause any danger for mammals.
The same receptor function is done with the TRPV1. It is also famous as the name of the capsaicin receptor. The rules and functions of all thermosensation properties are being seen on this receptor. Among all other properties, it is also seen that TRPV1 has the characteristics of an exhibition of analgesic property. Food intake regulation is the main function of this receptor and it is done by the process of energy Homeostasis. This experiment was also done on KO Mice to check the stability. During the rest, the weight of the mice has decreased and the change in food consumption was noticeable. Though TRPV1 is doing hardly 20 to 30% of the satiating job. Continuous experiments are proceeding to make possible the interactions between TRPV1 and OEA by the hyperphagic process.
In the field of medical science, the experiment and results bring a huge revolution. Around the World, the diseases due to heavyweight and excessive food intake are quite high. To prevent this, OEA is doing great help and these factors are responsible for that.Tags: Oleoylethanolamide